PreKUnil^®

LNAA Tablets

New enhanced LNAA formulation for the dietary management of PKU

Now contains:
Lysine and Vitamin B12 & B6

PreKUnil Phenylalanine free, Large Neutral Amino Acid (LNAA) tablets allow teenage and older individuals with proved PKU to follow a more relaxed diet plan.

PreKUnil's formulation of LNAA inhibits Phenylalanine transport across blood-brain barrier (BBB). High concentrations of LNAA compete with Phe, decrease the amount of Phe in the brain and thereby increase the possibility of normal neuropsychological performance.

PreKUnil tablets must be supplemented with moderately restricted PKU diet containing other sources of protein, fat, carbohydrates, vitamins and minerals. Dairy products such as cottage cheese, milk and yoghurt, along with fish and lean meat should be discussed or avoided.

Unlike the sensory characteristics of established formulas for PKU, the PreKUnil tablets are without any smell or taste, making them easy to intake with water.

PreKUnil tablets must be used under strict medical supervision.
PreKUnil tablets are not suitable as a sole sourse of nutrition.
PreKUnil tablets should not be used by maternal PKU patients.

Dosage and Administration

The recommended amount of tablets depends of lean body mass. Body weight x 0.4 = number of tablets

It is important to take the tablets in three or more dosage distributed over the day along with a meal. The blocking effect of Tyrosine and Tryptophan, preventing phenylalanine from entering the brain, does only work if food and PreKUnil tablets are taken either before or simultaneously with a meal.

The phenylalanine plasma concentration should be monitored regularly and kept below 1500µmol/L

Store in a cool, dry place.
Keep away from children.

 

Amino Acids:
L-Tyrosine, L-Tryptophane, L-Methionine, L-Isoleucine, L-Treonine, L-Valine, L-Leucine, L-Lysine, L-Histidine, L-Arginine

Vitamins:
B6, B12 

 

PreKUnil - more independence to the patients